Programme
"Research and Scholarships"

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Projects in Research activity: 11
Projects in Scholarships activity: 26
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Scholarships
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Research
Scholarships
University of Latvia (12 projectprojects)
Raiņa Bulvāris 19, Rīga, LV-1586
Gender, Culture and Power: Diversity and Interactions in Latvia and Norway
Latvia - Norway
Latvia - Latvia
Technology transfer in the processing of mineral resources in earlier times (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
EU Policies impact to the Transformations of the Higher Education and Research system in Norway and latvia
Latvia - Latvia
Latvia - Norway
Benefits and detrimental effects of sequence variants of Amyloid-β: towards the use of small peptides for aggregate dissolution therapy in dementia
Latvia - Norway
Latvia - Latvia
Establishing of the scientific capacity for the management of pharmaceutical products residues in the environment of Latvia and Norway (PROJECT COMPLETED)
Latvia - Norway
Educational collaboration between Norway and Latvia for establishment of an effective risk assessment and control of pharmaceutical residues
Latvia - Norway
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Latvia - Norway
Latvia - Latvia
Strengthening and transferring the intellectual capital among geographers in Latvia and Norway
Latvia - Norway
Mobility in political science and sociology
Latvia - Norway
Mobility in Language, Culture and Gender Studies
Latvia - Iceland
Latvia - Norway
Economics and Management Student and Teacher Mobility between University of Latvia and University of Agder
Latvia - Norway
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
Latvian Biomedical Research and Study Centre (3 projectprojects)
Rātsupītes iela 1, Rīga, LV-1067, Latvija
Image-guided cancer gene therapy in combination with advanced chemotherapeutics (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Cancer derived extracellular vesicles: function and clinical applications in prostate cancer (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Latvia - Norway
Latvia - Latvia
Riga Teacher Training and Educational Management Academy (4 projectprojects)
Imantas 7. līnija 1, Rīga, LV-1083, Latvija
Latvian language in monolingual and bilingual aquisitions: tools, theories and applications (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Health ans Social Indicators of participation in Physical Activities for Children with Disabilities
Latvia - Latvia
Latvia - Norway
Educational for Sustainable Development
Latvia - Norway
Research-based Teaching of Language Acquisition (in synergy with Research activity project "Latvian language in Monolingual and Bilingual Acquisition: tools, theories and applications")
Latvia - Norway
University of Latvia, Faculty of Humanities (1 projectprojects)
Raiņa bulvāris 19, Rīga, LV-1586
Latvian language in monolingual and bilingual aquisitions: tools, theories and applications (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Institute of Mathematics and Computer Science, University of Latvia (1 projectprojects)
Raiņa bulvāris 29, Rīga, LV-1459
Latvian language in monolingual and bilingual aquisitions: tools, theories and applications (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Institute of Latvian History, University of Latvia, (1 projectprojects)
Raiņa bulvāris 19, Rīga, LV-1586
Technology transfer in the processing of mineral resources in earlier times (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Latvia University Institute of Philosophy and Sociology (1 projectprojects)
Raiņa Bulvāris 19, Rīga, LV-1586
Rural Depopulation and the Governance of Education. Comparative Study of latvia and Norway (PROJECT COMPLETED)
Latvia - Norway
Latvian Academy of Sport Education (2 projectprojects)
Brīvības gatve 333, Rīga, LV-1006, Latvija
Health ans Social Indicators of participation in Physical Activities for Children with Disabilities
Latvia - Latvia
Latvia - Norway
Innovative Physical Activity Measures in Health and Sport Science Studies
Latvia - Norway
Institute of Electronics and Computer Science (1 projectprojects)
Dzērbenes iela 14, RĪGA, LV-1006
Health ans Social Indicators of participation in Physical Activities for Children with Disabilities
Latvia - Latvia
Latvia - Norway
Stockholm School of Economics in Riga (1 projectprojects)
Strēlnieku iela 4a, LV 1010 RĪGA
EU Policies impact to the Transformations of the Higher Education and Research system in Norway and latvia
Latvia - Latvia
Latvia - Norway
Riga Technical University (5 projectprojects)
Kaļķu iela 1, Rīga, LV–1658, Latvija
EU Policies impact to the Transformations of the Higher Education and Research system in Norway and latvia
Latvia - Latvia
Latvia - Norway
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Information Technology)
Latvia - Iceland
Latvia - Liechtenstein
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Mechanics)
Latvia - Iceland
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Architecture)
Latvia - Liechtenstein
Building Bridges between Latvia and Norway in Higher Education in Chemistry
Latvia - Norway
Organic Synthesis Institute of Latvia (2 projectprojects)
Aizkraukles 1, LV-1006, Rīga
Image-guided cancer gene therapy in combination with advanced chemotherapeutics (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Benefits and detrimental effects of sequence variants of Amyloid-β: towards the use of small peptides for aggregate dissolution therapy in dementia
Latvia - Norway
Latvia - Latvia
University of Latvia, Faculty of Medicine (1 projectprojects)
Raiņa bulvāris 19, Rīga, LV-1586
Cancer derived extracellular vesicles: function and clinical applications in prostate cancer (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Riga Stradiņš University (3 projectprojects)
Dzirciema iela 16, Rīga, LV-1007, Latvija
Innovative approach to hull-less spring cereals and triticale use from human health perspective (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Role of social and economic networks in territorial development
Latvia - Latvia
Latvia - Iceland
Capacity building organizing the scholarship activities for students and academic staff at the Riga Stradiņš University
Latvia - Norway
Latvian Academy of Culture (1 projectprojects)
Ludzas iela 24, Rīga, LV-1003, Latvija
Students` Mobility
Latvia - Iceland
Latvia - Norway
BA School of Business and Finance (1 projectprojects)
Kr.Valdemāra iela 161, Rīga, LV-1013, Latvija
Internationalization through Student and Academic Staff Mobility in Business Administration Programs
Latvia - Norway
Art Academy of Latvia (1 projectprojects)
Kalpaka bulvāris 13, Rīga, LV-1867, Latvija
Mobility project between higher education institutions of Latvia and Norway in the field of art and design
Latvia - Norway
Daugavpils University (2 projectprojects)
Vienības iela 13, Daugavpils, LV-5400, Latvija
Role of social and economic networks in territorial development
Latvia - Latvia
Latvia - Iceland
Establishing of Scholarships for Language and Culture Studies in Latvia and Norway with the Focus on Studies of Monuments to Famous Persons and Their Testing for the Needs of Tourism
Latvia - Norway
Latvia University of Agriculture (5 projectprojects)
Lielā iela 2, Jelgava, LV-3001, Latvija
Innovative approach to hull-less spring cereals and triticale use from human health perspective (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Mobility in the field of Food Technology
Latvia - Norway
Mobility in the field of Architecture and Civil Engineering
Latvia - Norway
Mobility in the field of Information Technologies
Latvia - Norway
Mobility in the field of agriculture, forestry and veterinary medicine
Latvia - Norway
Rezekne Academy of Technologies (2 projectprojects)
Atbrīvošanas aleja 115, Rēzekne, LV-4601, Latvija
Gender, Culture and Power: Diversity and Interactions in Latvia and Norway
Latvia - Norway
Latvia - Latvia
Innovation curricula, research and support – systematic approach within university context
Latvia - Norway
Institute of Agroresources and Economics (1 projectprojects)
Zinātnes iela 1a, Priekuļi, Priekuļu novads, LV-4126
Innovative approach to hull-less spring cereals and triticale use from human health perspective (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Vidzeme University of Applied Sciences (2 projectprojects)
Cēsu iela 4, Valmiera, LV-4201, Latvija
Role of social and economic networks in territorial development
Latvia - Latvia
Latvia - Iceland
Mobility scholarships for academic staff and students to expand understanding about the digital media audiences
Latvia - Norway
Norwegian Institute of Bioeconomy Research (NIBIO) (1 projectprojects)
Fredrik A. Dahls street 20, Ås, Akershus, 1432
Innovative approach to hull-less spring cereals and triticale use from human health perspective (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Norwegian University of Life Sciences (3 projectprojects)
Universitetstunet 3, Ås, Akershus, NO-1430, Norvēģija
Mobility in the field of Food Technology
Latvia - Norway
Mobility in the field of Architecture and Civil Engineering
Latvia - Norway
Mobility in the field of Information Technologies
Latvia - Norway
University of Bergen (2 projectprojects)
Muséplass 1, Postboks 7800, Bergen, N-5020, Norvēģija
Capacity building organizing the scholarship activities for students and academic staff at the Riga Stradiņš University
Latvia - Norway
Strengthening and transferring the intellectual capital among geographers in Latvia and Norway
Latvia - Norway
Bergen Academy of Art and Design (1 projectprojects)
Strømgaten 1, Bergen, N-5005, Norvēģija
Mobility project between higher education institutions of Latvia and Norway in the field of art and design
Latvia - Norway
Buskerud and Vestfold University College (BVUC) (1 projectprojects)
Raveien 215, Borre, 3184, Norvēģija
Establishing of Scholarships for Language and Culture Studies in Latvia and Norway with the Focus on Studies of Monuments to Famous Persons and Their Testing for the Needs of Tourism
Latvia - Norway
University of Oslo (9 projectprojects)
Boks 1072 Blindern, Oslo, 0316, Norvēģija
Latvian language in monolingual and bilingual aquisitions: tools, theories and applications (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Benefits and detrimental effects of sequence variants of Amyloid-β: towards the use of small peptides for aggregate dissolution therapy in dementia
Latvia - Norway
Latvia - Latvia
Establishing of the scientific capacity for the management of pharmaceutical products residues in the environment of Latvia and Norway (PROJECT COMPLETED)
Latvia - Norway
Educational collaboration between Norway and Latvia for establishment of an effective risk assessment and control of pharmaceutical residues
Latvia - Norway
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
University of Oslo, Institute of Clinical Medicine (1 projectprojects)
P.O. Box 1072, Oslo, 0316, Norvēģija
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Latvia - Norway
Latvia - Latvia
University of Oslo, Institute of Basic Medical Sciences (1 projectprojects)
P.O. Box 1072, Oslo, 0316, Norvēģija
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Latvia - Norway
Latvia - Latvia
Centre of Gender Research at the University of OSLO (1 projectprojects)
P.O. Box 1040 Blindern, Oslo, N-0315, Norvēģija
Gender, Culture and Power: Diversity and Interactions in Latvia and Norway
Latvia - Norway
Latvia - Latvia
Museum of Cultural History University of OSLO (1 projectprojects)
P.O. Box 6762 St. Olavs plass, OSLO, 0130
Technology transfer in the processing of mineral resources in earlier times (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Oslo and Akershus University College of Applied Sciences (HiOA) (1 projectprojects)
Gaustadalléen 21, OSLO, 0349
Rural Depopulation and the Governance of Education. Comparative Study of latvia and Norway (PROJECT COMPLETED)
Latvia - Norway
Norwegian School of Sport Science (1 projectprojects)
Sognsveien 220, Oslo, 0863, Norvēģija
Health ans Social Indicators of participation in Physical Activities for Children with Disabilities
Latvia - Latvia
Latvia - Norway
Nordic Institute for Studies in Innovation,Research &Education (NIFU) (1 projectprojects)
Wergelandsveien 7 , OSLO, N-0167
EU Policies impact to the Transformations of the Higher Education and Research system in Norway and latvia
Latvia - Latvia
Latvia - Norway
Oslo University Hospital (2 projectprojects)
Postboks 4950 Nydalen, OSLO, 0424
Image-guided cancer gene therapy in combination with advanced chemotherapeutics (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Cancer derived extracellular vesicles: function and clinical applications in prostate cancer (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Oslo National Academy of the Arts (1 projectprojects)
Fossveien 24/P.O.Box. 6853 St. Olavplass, Oslo, 0130, Norvēģija
Mobility project between higher education institutions of Latvia and Norway in the field of art and design
Latvia - Norway
Oslo and Akershus University College of Applied Sciences (1 projectprojects)
P.O. Box 4 St. Olavs plass, Oslo, N-0130, Norvēģija
Mobility in political science and sociology
Latvia - Norway
Institute of Health and Society, University of Oslo (1 projectprojects)
Box 1072, Blindern, Oslo, NO-0316, Norvēģija
Mobility in Language, Culture and Gender Studies
Latvia - Iceland
Latvia - Norway
Centre for Gender Research at the University of Oslo (1 projectprojects)
P.O. Box 1040 Blindern, Oslo, N-0315, Norvēģija
Mobility in Language, Culture and Gender Studies
Latvia - Iceland
Latvia - Norway
Norwegian School of Sport Science (1 projectprojects)
Sognsveien 220, Oslo, 0863, Norvēģija
Innovative Physical Activity Measures in Health and Sport Science Studies
Latvia - Norway
University of Tromso (4 projectprojects)
Hansine Hansens veg 18, Tromsø, 9019, Norvēģija
Latvian language in monolingual and bilingual aquisitions: tools, theories and applications (PROJECT COMPLETED)
Latvia - Norway
Latvia - Latvia
Research-based Teaching of Language Acquisition (in synergy with Research activity project "Latvian language in Monolingual and Bilingual Acquisition: tools, theories and applications")
Latvia - Norway
Mobility in Language, Culture and Gender Studies
Latvia - Iceland
Latvia - Norway
Building Bridges between Latvia and Norway in Higher Education in Chemistry
Latvia - Norway
Arctic University of Norway (1 projectprojects)
Bok 5060 Langnes, Tromso, N-9037, Norvēģija
Strengthening and transferring the intellectual capital among geographers in Latvia and Norway
Latvia - Norway
Norwegian University of Science and Technology (NTNU), Department of Public Health and General Practice (1 projectprojects)
Post box 8905 MTFS, Trondheima, 7491, Norvēģija
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Latvia - Norway
NLA University College Gimlekollen, Gimlekollen School of Journalism and Communication (1 projectprojects)
Bergtoras vei 120, Kristiansand, 4604, Norvēģija
Mobility scholarships for academic staff and students to expand understanding about the digital media audiences
Latvia - Norway
University of Agder, School of Business and Law (1 projectprojects)
Servicebox 422, Kristiansand, N-4604, Norvēģija
Economics and Management Student and Teacher Mobility between University of Latvia and University of Agder
Latvia - Norway
Ostfold University College (1 projectprojects)
Bra veien 4, Halden, 1757, Norvēģija
Mobility in political science and sociology
Latvia - Norway
Hedmark University College (1 projectprojects)
Terningen Arena, Hamarvegen 112, Elverum, 2411, Norvēģija
Mobility in the field of agriculture, forestry and veterinary medicine
Latvia - Norway
Lillehammer University College (1 projectprojects)
Gudbrandsdalsveien 350, Lillehammer, N-2604, Norvēģija
Educational for Sustainable Development
Latvia - Norway
Telemark University College (1 projectprojects)
Kjølnes ring 56, Porsgrunn, 3918, Norvēģija
Internationalization through Student and Academic Staff Mobility in Business Administration Programs
Latvia - Norway
University of Stavanger (1 projectprojects)
Kjell Arholms gate 41, Stavanger, 4021, Norvēģija
Innovation curricula, research and support – systematic approach within university context
Latvia - Norway
Volda University College (1 projectprojects)
Joplassvegen 11, Volda, NO6101, Norvēģija
Students` Mobility
Latvia - Iceland
Latvia - Norway
University of Iceland (3 projectprojects)
Sæmundargötu 2, Reykjavík, 101, Islande
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Information Technology)
Latvia - Iceland
Latvia - Liechtenstein
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Mechanics)
Latvia - Iceland
Mobility in Language, Culture and Gender Studies
Latvia - Iceland
Latvia - Norway
University of Iceland, School of Humanities (1 projectprojects)
Aðalbygging Háskóla Íslands Sæmundargata 2, Reykjavík, 101, Islande
Mobility in Language, Culture and Gender Studies
Latvia - Iceland
Latvia - Norway
University of Akureyri (2 projectprojects)
Norðurslóð 2, Akureyri, 600, Islande
Students` Mobility
Latvia - Iceland
Latvia - Norway
Role of social and economic networks in territorial development
Latvia - Latvia
Latvia - Iceland
University of Liechtenstein (2 projectprojects)
Fürst-Franz-Josef-Strasse, Vaduz, 9490, Lihtenšteina
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Information Technology)
Latvia - Iceland
Latvia - Liechtenstein
Student and Academic Staff Mobility within the EEA Grant Scholarship Activity (Architecture)
Latvia - Liechtenstein
Gender, Culture and Power: Diversity and Interactions in Latvia and Norway
Technology transfer in the processing of mineral resources in earlier times (PROJECT COMPLETED)
EU Policies impact to the Transformations of the Higher Education and Research system in Norway and latvia
Benefits and detrimental effects of sequence variants of Amyloid-β: towards the use of small peptides for aggregate dissolution therapy in dementia
Establishing of the scientific capacity for the management of pharmaceutical products residues in the environment of Latvia and Norway (PROJECT COMPLETED)
Educational collaboration between Norway and Latvia for establishment of an effective risk assessment and control of pharmaceutical residues
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Strengthening and transferring the intellectual capital among geographers in Latvia and Norway
Mobility in political science and sociology
Mobility in Language, Culture and Gender Studies
Economics and Management Student and Teacher Mobility between University of Latvia and University of Agder
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
  • Project data
  • About project
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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Gender, Culture and Power: Diversity and Interactions in Latvia and Norway
Project funds
283030.00 EUR
Project term
01.06.2015 - 30.04.2017
Project Nr.
NFI/R/2014/061
Synergy project Nr.
Partner
Centre of Gender Research at the University of OSLO
P.O. Box 1040 Blindern, Oslo, N-0315, Norvēģija

E-mail: postmottak@stk.uio.no
http://www.stk.uio.no/english/
Hoffart, Amund Rake
Phone: +4722858973
E-mail: a.r.hoffart@stk.uio.no

Rezekne Academy of Technologies
Atbrīvošanas aleja 115, Rēzekne, LV-4601, Latvija

Project overall objective is to revive academic and public interest to feminist and gender theories in connection to current social reality and European political culture, to add new interdisciplinary dimensions to the already existing research mainstream, and to shed light on women's political and public activity by shaping a dialogue between various disciplines and cultures. The project aims at bringing new understanding to women and gender history of the European civilization, as well as considers the phenomenon of gender in connection to other reference fields (everyday history, politics, philosophy, literature, memoir studies, journalism, pedagogy, products of activity of various social and national groups). The project will develop effectiveness of gender politics in Latvia by providing political, social and academic sustainability of gender discourse in civic culture of Latvian society. To secure the sustainability of the civic activism in gender politics in Latvia, contemporary European politics of gender equality and recognition politics should become more present among various stakeholders of the Latvian gender political discourse. That is why the experience of Norway in gender research and politics will serve as the content and channel for revitalizing general political culture of Latvia. The project focuses on creation of sustainable and effective space of civic engagement into gender and culture politics. Although the title of the project proposes both sexes/genders, the project focuses mostly on women, since in the light of the overall project objective it is of higher significance. The concept of gender is culturally differentiated because each culture perceives it in its own way, frequently creating the dissonance between power and culture, between general normative acts and their perception in society. Therefore, the concept of gender should be defined in the context of national cultural and political history. Thus the dissemination activities will be spread into two directions: national and international (global). The complex dissemination strategies will be used, starting with the set of recommendations for the State Level decision makers and for university study programmes and up to mass media and the other public discourses.

Synergy project
The project is being implemented in synergy with the EEA/Norway Grants' scholarship project No. EEZ/NFI/S/2015/022. Master and PhD students' involvement in research project through data collection, assisting in drafting and co-authoring publications on research results, development of research project-based doctoral thesis; involvement of academic staff in research project to design the lecturing course for the PhD school and develop new study courses involving Norwegian experience on gender sociality and female studies issues.

Reporting period 01.05.2015. - 31.12.2015.

The work in all directions set by the general objectives of the project has been initiated during the first reporting period. All planned for the first reporting period results have been achieved (8 scholarly papers at the international scientific conference by A. Cimdiņa, E. Buceniece, M. Kūle, N. Šroma, Z. Kārkla, A. Auziņa, S. Kušnere, I. Narodovska).

The research cooperation among Project partner institutions (University of Latvia, Centre for Gender Research at the University of Oslo, Rezekne Academy of Technologies) has been intensified by the co-organization and participation in the dissemination activities (the international conference “Gender, Culture and Power Interactions”, the link: www.aspazija.lu.lv; the worked-out draft of the Agenda of the seminar “Gender and Feminist Research Methodology” in Rezekne). The research work and dissemination activities of all four work packages have been initiated, covering the following thematic framework: History, Theory and Reception of Feminism and Gender Studies in Latvia; Gender, Literature, Politics, and Women’s Texts; Gender, Nation-Building and Ethnic/National Minorities; Postcolonial Discourse in Gender, Culture and Society Studies.

The cooperation with NGO (Open Stores) and municipalities (Jūrmala/Rīga) in activities directed towards the dissemination of the project results. The dialogue with society (as the basis for the preparation of the draft recommendations in gender politics) at the Forum “Marriage, Family and Child in the Contemporary Crisis Society” has been initiated.

The list of glossary entries (in the field of Cultural Feminism) has been selected and prepared for the final discussion with the Norwegian partner (at the seminar in Rezekne, in February, 2016).

The drafts (by D. Hanovs, V. Tēraudkalns, Emil Nicklas Johnsen) for three international peer reviewed publications have been worked out.

Synergy with the Scholarship Activity (“Mobility in Language, Culture and Gender Studies”) is being carried out (staff mobility to University of Oslo and University of Iceland; preparation of the PhD students’ mobility programme to Oslo), and resulted in the integration of the results into the course of the Faculty of Humanities, University of Latvia (“Gender in Literature: Discourse of Feminism” (A.Cimdiņa) and “Sociolinguistics” (I.Druviete)).

A PhD student (Anna Auziņa) and a post-doc (Zita Kārkla) are being trained within the project by integrating the Project results into a PhD thesis and further research.

Reporting period 01.01.2016 – 31.08.2016

The work in all directions set by the general objectives of the project has been initiated during the first reporting period and continued throughout the second reporting period. All planned for the second reporting period results have been achieved:

  • 10 scientific publications in the collective monograph “Aspazija and Mobility: Gender, Nation, Creativity” by the following researchers: A. Cimdiņa, E. Buceniece, M. Kūle, N. Šroma, Z. Kārkla, E. Eglāja, A. Auziņa, S. Kušnere, I. Narodovska, L. Sproģe (Zinātne, 2016);
  • 6 papers presented at the seminar “Gender, Diversity and Interactions in Latvia and Norway” in Oslo (March 9, 2016).

Additionally, 2 peer-reviewed articles have been published: Sieviete kā simbolisks resurss (Deniss Hanovs); Vīriešu kustības Rietumu kristietībā no 19. līdz 21. gadsimtam (Valdis Tēraudkalns) in a peer-reviewed collection of articles "Dzimtes konstruēšana III" (2016). Other peer-reviewed articles are in preparation.

The research cooperation among Project partner institutions (University of Latvia, Centre for Gender Research at the University of Oslo, Rezekne Academy of Technologies) has been intensified by the co-organization and participation in the dissemination activities:

  • The seminar “Gender and Feminist Research Methodology” in Rezekne on the 11th-12th of February, 2016. The programme of the seminar.
  • The seminar “Gender, Diversity and Interactions in Latvia and Norway” at the Centre for Gender Research at the University of Oslo on the 9th of March, 2016. The programme of the seminar.

The research work and dissemination activities of all four work packages have been continued, covering the following thematic framework: History, Theory and Reception of Feminism and Gender Studies in Latvia; Gender, Literature, Politics, and Women’s Texts; Gender, Nation-Building and Ethnic/National Minorities; Postcolonial Discourse in Gender, Culture and Society Studies. Intense work on the theory and methodology of gender and feminist research during two theoretical seminars in Rezekne and Oslo has been conducted in interdisciplinary dimension, covering all of the subfields: Political history, General and comparative literature, literary criticism, literary theory; Baltic and Slavonic languages and literatures; Scandinavian languages and literatures; History and philosophy of the social sciences; Social changes, theory of social work; Cultural anthropology, ethnology; Systematic philosophy, ethics, aesthetics, metaphysics, epistemology, ideology.

The cooperation with NGO and municipalities (Rēzekne) in activities directed towards the dissemination of the project results has been continued. The dialogue with society (as the basis for the preparation of the draft recommendations in gender politics) has been continued with the help of two dissemination activities:

  • A. Cimdiņa participated in the interdisciplinary academic discussion “Dzimte? Dzimums? Starpdisciplīnu akadēmiskā diskusija par dzimumu līdztiesības jēdzieniem” on the 11th of March, 2016. The organizers: Ministry of Welfare and the Faculty of Social Sciences of the University of Latvia. The additional information available here.
  • N. Šroma (WP1) discussed the contents of the project in the frames of the programme “Theory of Everything” at LR4 (Latvian Radio 4) on the 31st of May, 2016. The programme is available here.

The list of glossary entries (in the field of Cultural Feminism) has been selected discussed with the Norwegian partner (at the seminar in Rezekne, on the 11th-12th of February, 2016). The entries are in the process of preparation for the publication in 2017.

Synergy with the Scholarship Activity (“Mobility in Language, Culture and Gender Studies”) has been carried out: The student mobility (Anna Auziņa) to the Centre for Gender Research at the University of Oslo that resulted into the inclusion of the experience of the Norwegian colleagues into the PhD thesis and project research (glossary entries).

PhD students (Anna Auziņa, Sigita Kušnere) and post-docs (Zita Kārkla, Pauls Daija, Anastasija Vedela) are being trained within the project by integrating the Project results into a PhD thesis and/or further research.

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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Technology transfer in the processing of mineral resources in earlier times (PROJECT COMPLETED)
Project funds
480850.00 EUR
Project term
01.06.2015 - 30.04.2017
Project Nr.
NFI/R/2014/062
Partner
Museum of Cultural History University of OSLO
P.O. Box 6762 St. Olavs plass, OSLO, 0130
Institute of Latvian History, University of Latvia,
Raiņa bulvāris 19, Rīga, LV-1586

The overall objective of the project is to obtain a comprehensive picture of the development of technologies for processing key mineral resources in prehistory and early historical periods in Latvia (lithic blade technology of the Stone Age; iron smelting in later periods), focussing on the role of transfers of technology across geographical space and between different societies and cultures, and thus contributing to the general understanding of technologies and technological change in Northern Europe in pre-industrial ages. The project envisages a novel approach to the study of the pre-industrial technologies used in the processing of major mineral resources, namely lithic materials and iron ore, which were of crucial socioeconomic significance in early prehistory and in later prehistory/early historical times, respectively. Recent research has highlighted the importance of technology transfers in shaping the pattern of use of both resources: this will provide the overall focus and common thread of the study, which will consider archaeological and historical evidence mainly from Latvia, viewed in the broader Northern European context. The lithic study will involve technological analysis of key museum collections in Latvia, focussing on the role of regional technology transfers in the development of blade technology during the Stone Age. The research on late prehistoric/medieval/early modern iron production will likewise involve systematisation and technological analysis of previously recovered material (both archaeological and written records), but will also include a major element of field research and laboratory analysis – targeted specifically at sites relating to the extensive iron production activities in the former Duchy of Courland and Semigallia (W and S Latvia, 16th–18th cent.). Here, the transfers of iron production technology across Northern Europe from late prehistory up to the Early Modern Era will be the key focus. The project includes a major element of experimental archaeology: knapping experiments and the reconstruction of a bloomery furnace. The research findings will be discussed in a workshop on technology transfer in the processing of mineral resources and will be disseminated through conference papers and publications at the international and national level. Major new insights can be expected on past technologies and technological change, propelling forward research in this field in Latvia and delivering results significant at the European level.

Project final report: ?d=NFIR2014062_final_report.pdf (EN)
Scientific report: ?d=3_3_final_report_ENG.pdf (EN)
Presentations: ?d=gala_rezultati_prezentacijas_final_results_presentations.zip

During the final reporting period a five-day project workshop took place in Riga, during which an international scientific conference “Flint and iron in the course of history: technology transfer in the processing of mineral resources in earlier times” was held as an event open to the public, presenting the main results of the project.

The analysis of ore, slag and metal samples in the frame of iron production studies was completed, as were the project databases and reports.

Eight publications presenting the results and conclusions of research on lithic technology and iron production were prepared and submitted: six of them for international journals, and two for a Latvian journal. Five of these publications were written jointly by the Latvian and Norwegian experts.

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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
EU Policies impact to the Transformations of the Higher Education and Research system in Norway and latvia
Project funds
628821.00 EUR
Project term
01.06.2015 - 28.02.2017
Project Nr.
NFI/R/2014/006
Partner
Stockholm School of Economics in Riga
Strēlnieku iela 4a, LV 1010 RĪGA
Riga Technical University
Kaļķu iela 1, Rīga, LV–1658, Latvija
Nordic Institute for Studies in Innovation,Research &Education (NIFU)
Wergelandsveien 7 , OSLO, N-0167

Overall objective of the project is to enhance higher education and research in Latvia and Norway. Project results and future development will contribute to the quality and effectiveness of the leadership and governance in the field of research and higher education in Europe. The current EU policy documents call for major changes that higher education and research institutions should undergo to respond to global challenges posed by the new environment at universities and research institutes, including innovations, knowledge-driven development, intellectual property rights, and academic entrepreneurship. The current HEIs do not perform to their capacity. This project is focusing on academic and research environments to make them more efficient by becoming entrepreneurial organizations in terms of leadership and governance, organisational capacity, development in teaching and learning, university – business/external relationships for knowledge exchange as outlined in the Guidelines for Entrepreneurial Universities. The project aims at exploring ways how to expand strategic partnerships with national and international stakeholders in order to secure sustainable development of higher educational institutions in line with EU policies. The project would apply the roadmap approach and focus on EU and field related policy documents in Latvia and Norway. The results of the project would be useful for the development of the higher education and research environment in Europe. The project would involve Ph. D. students and thus strengthen the human resource competencies in the area of institutional research. Although the project would focus primary on Latvia and Norway, the results would be useful for other EU countries and it would open up opportunities for further cooperation within the framework of Horizon 2020.

Project progress until 31.01.2016.

The project has focused on the analysis of the current EU policy documents regarding higher education and research institutions in order to explore the new environment at HEIs, including innovations, knowledge-driven development, intellectual property rights, and academic entrepreneurship. Currently the analytical framework „EU policies impact on the transformations of the higher education and research system in Norway and Latvia” was developed. This paper defined term of Europenization of higher education institutes and defining policy making modes in higher education area. In addition the National framework is developed that sets out the theoretical framework and research question for further data collection, as well as analyses participation of Latvia in EU Framework programmes. These two papers laid ground for the framework development for data collection – case study protocol and framework for questionnaires.

Preliminary findings have been reported in two sessions at the 74 annual conference of the University of Latvia. Papers for two more conferences are submitted. Two webpages are created for the purpose of informing academic community and wider society on the progress of the project. Overall the project is within schedule, with some adjustments.

Project progress until 30.09.2016.

The project continued on the analysis of the current EU policy documents regarding higher education and research institutions, including innovations, knowledge-driven development, intellectual property rights, and academic entrepreneurship. The analysis is based on the project framework document „EU policies impact on the transformations of the higher education and research system in Norway and Latvia” the National framework document.

This far four main HE capacity elements that have impact on teaching and research capacity are identified:

  • policy making capacity (what are the aims, desired outcome, are policies linked to other policies, policy implementation process etc.),
  • legal capacity (normative base, accreditation system, potential of state organizations etc.),
  • funding capacity (including national resources and European funding as Horizon 2020, Erasmus+, etc.),
  • information capacity (benchmarking exercises, exchange of good practices etc.).

The findings have been reported in several conferences such as the 57 annual conference of the Riga Technical University, European Consortium of Political Research (ECPR, Prague, Czech republic, 19th QMOD conference jointly organized by Lunds Unversity, Linköping University of Sweden and University of Roma Tre in Rome, Italy; and Comparative International Education Society, Vancouver, Canada. Webpage http://transfer.rtu.lv/ is maintained for the purpose of informing academic community and wider society on the progress of the project. Overall the project is within schedule, with some adjustments.

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Promoter
Organic Synthesis Institute of Latvia
Address
Aizkraukles 1, LV-1006, Rīga
Project name
Benefits and detrimental effects of sequence variants of Amyloid-β: towards the use of small peptides for aggregate dissolution therapy in dementia
Project funds
490089.00 EUR
Project term
01.05.2015 - 30.04.2017
Project Nr.
NFI/R/2014/023
Synergy project Nr.
Homepage
Partner
University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija
University of Latvia
Raiņa Bulvāris 19, Rīga, LV-1586

The overall goal of this project is to develop the new strategy for the treatment of the Alzheimer disease (AD) and to enhance research-based knowledge in Latvia through a long term collaboration of OSI, LU and UiO. The Lativian research groups at OSI will provide their expertise in structural analyses to start an iterative set of experiments. The UiO will provide knowledge and expertise in the field of disease models and analyses. The LU partners will have access to world-wide unique mouse models, and are skilled in the performance of behavioural and cognitive tests. Neurodegenerative diseases represent an increasing threat to the society and families in both countries. Deposition of toxic proteins in the brain leads to dementia, motor dysfunction, and psychiatric problems. Despite enormous efforts, so far, the pathomechanism of the most abundant form of these diseases, sporadic AD, has not been revealed and treatment is not available. Aggregation of intracerebrally generated Aβ peptides is the main reason for pathological deposits. It has been discovered by the Pahnke lab that removal of toxic peptide monomers is indeed an innovative option for treatment and prevention of dementia. Furthermore, it was first found in an Italian family that specific mutations in the N-terminal part of Aβ lead to the protection of heterocygote carriers by reducing the aggregation propensity. Based on this information, the project will set up a joint programme to investigate whether amino acid changes could be exploited as an innovative method to dissolve higher order Aβ aggregates and to enhance clearance of Aβ from the brain into the blood stream. The extensive expertise of the team at the OSI will be used to decipher structural differences of specific mutations and co-aggregated peptides. The resulting data will be used to iterate in vivo experiments. The opportunity of exchange of Latvian students to Norway for in vivo investigations and methods transfer will be used as well.

Synergy project
The project is being implemented in synergy with the EEA/Norway Grants' scholarship project No. EEZ/NFI/S/2015/019 and research project No. NFI/R/2014/045. Related to NFI/R/2014/023, Latvian PhD students will be trained for stereotactic mouse surgery and infusion techniques in Norway. They will achieve further knowlege through seminars held within consortium. Treatment approaches of amyloid extrusion over the barriers of the brain, antibody based or ABC transporter based , will significantly improve when combined with the approaches generated thoughout the project. Related to NFI/R/2014/045, the project team includes PhD and MSc degree students affiliated to LU whose individual study plan will be tailored to include visits to the Oslo University Hospital (OUS) in conjunction with the Scholarship activity. Consortium activities will be planned in synergy to allow research team mobility and knowledge exchange between OUS and LU. The main tasks of the visits will be to develop standard procedures for the isolation of EVs from biofluids and to gain experience in studying the mechanisms of EV release and uptake.

On 15 February 2016 the project partners – University of Oslo – participated at the meeting with the Programme Committee and the Cooperation Committee members and held a presentation on the project progress, expected outcomes and the involvement of Norwegian researchers and academic staff in research and scholarship project activities. The presentation is available here: ?d=2016_02_15_eez_023.pdf


OVERALL PROJECT PROGRESS until 31.12.2015.

OSI is working on in vitro assays (mainly NMR and Thioflavin T) for interaction studies between Aβ and Aβ fragments (A2V and A2T full-length and hexapeptide have been tested so far). Optimization of molar ratio, buffers etc. have been established. Results have been compiled into a first draft of a manuscript.  LU researchers are investigating the short sequence peptides using in vivo models (by implementing behavioral and cognitive methods) and ex vivo methods (immunohistochemical staining and western blotting) in tight collaboration with both other partners: the Organic Synthesis Institute of Latvia and University of Oslo. Methodology has been established and reference compounds tested, the obtained data have been processed for the potential manuscripts.


Project progress in IOS from 01.05.2015. till 31.07.2015.

The design and preparation of amyloid-beta peptide expression constructs with different sequences has been made :
1) amyloid-beta peptide 1-40;
2) amyloid-beta peptide 1-42;
3) amyloid-beta peptide 1-42 mutant A2V;
4) amyloid-beta peptide 1-42 mutant A2T.
Work has begun on the production and purification of these peptides.
Published on 10.08.2015.


Project progress in IOS from 01.08.2015. till 31.10.2015.

The production, purification and analysis of amyloid-beta peptide variants with different sequences has been done.
The following peptides were obtained for further studies:
1) amyloid-beta peptide 1-40;
2) amyloid-beta peptide 1-42;
3) amyloid-beta peptide 1-6 mutant A2V;
4) amyloid-beta peptide 1-6 mutant A2T.
Initial interaction studies between amyloid-beta peptide 1-42 and amyloid-beta peptide 1-6 mutant A2V were performed.
Published on 09.11.2015.


Project progress 
from 31.01.2016. till 30.04.2016.

WP1
LIOS have made two constructs based on Aβ(A2V)1-6 with two different cell penetrating peptides tags to assist passage over the blood brain barrier, TAT-Aβ(A2V)1-6 and AntP-Aβ(A2V)1-6. A new method for overexpression of Aβ and variants thereof has also been established. All these new constructs are currently being investigated.
WP2
To reveal the positive effects of different mutated amyloid beta peptides, in vivo experiments (surgical implantation of Alzet pumps carrying different amyloid beta peptides) are taking place in the laboratory of the Norwegian partner Prof. Jens Pahnke.

LU researchers are investigating the short sequence peptides using in vivo models (by implementing behavioral and cognitive tests) and ex vivo methods (immunohistochemical staining and western blotting).

Staff mobility from LU to the University of Oslo has been done in order to obtain high quality skills in animal database acquisition, surgery with Alzet pumps on mice and method validation.
Published on 10.05.2016.

 

Project progress from 31.01.2016. till 30.04.2016.

Alzheimer’s disease (AD) is a widespread neurodegenerative disease. Around 2040 the number of patients suffering from AD will be about 80 million. Up to now a specific therapy for AD is not available and stands as a major challenge for the researchers.

The most intensively studied pathological hallmark of AD is extracellular aggregated beta-amyloid peptide senile plaques. Progressive deponation of mentioned pathologically folded proteins and their accumulation in the brain tissues causes a massive neural dysfunction that leads to the dramatic decrease in overall functioning of the central nervous system.

The aim of the collaboration between three institutions (LU, OSI and UiO) is to create a novel approach in the area of AD therapy. This approach is based on the possibility of dissolving beta-amyloid aggregates in the central nervous system and providing their elimination from the brain through blood circulation. OSI is working on in vitro assays (mainly NMR and Thioflavin T) for interaction studies between hAβ and Aβ fragments (Aβ(WT)1-6, Aβ(A2V)1-6, Aβ(A2T)1-6, mAβ1-42, Aβ(R5G), Aβ(Y10F) and Aβ(H13R) have been tested so far). We have also made two constructs based on Aβ(A2V)1-6 with two different cell penetrating peptides tags to assist passage over the blood brain barrier, TAT-Aβ(A2V)1-6 and AntP-Aβ(A2V)1-6. A new method for overexpression of Aβ and variants thereof has also been established where we make use of a solubility tag from spider-silk protein. All these new constructs are currently being investigated. Results obtained so far has been compiled into a first draft of a manuscript.

LU researchers are investigating the short sequence peptides using in vivo models (by implementing behavioral and cognitive methods) and ex vivo methods (immunohistochemical staining and western blotting) in tight collaboration with both other partners: the Organic Synthesis Institute of Latvia and University of Oslo.

To reveal the positive effects of different mutated amyloid beta peptides, in vivo experiments (surgical implantation of Alzet pumps carrying different amyloid beta peptides) are taking place in the laboratory of the Norwegian partner Prof. Jens Pahnke. Western blot method validation for the assessment of the toxic amyloid beta 42 and 40 in the transgenic mice brain with 6E10 antibody that recognizes both: APP protein ( ~ 100 kDa) and amyloid beta 42 and 40 ( ~ 4 kDa) has been performed.

Research project is performed in synergy with the Scholarship Activity ‘Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities’ No. EEZ/NFI/S/2015/019. Staff mobility (6 students from the University of Latvia Faculty of Medicine, 2 PhD students, Postdoctoral researcher and Senior researcher exchange to the University of Oslo, Department of Neuro-/-Pathology (PAT) Translational Neurodegeneration and Neuropathology Lab has been done at the first half of the 2016 in order to obtain high quality skills in animal database acquisition, surgergy with Alzet pumps on mice and method validation. Methodology has been established and reference compounds tested, the obtained data have been introduced into the manuscripts that are going to be published in the Journal of Pharmacological Research. 

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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Establishing of the scientific capacity for the management of pharmaceutical products residues in the environment of Latvia and Norway (PROJECT COMPLETED)
Project funds
218432.00 EUR
Project term
01.06.2015 - 30.04.2017
Project Nr.
NFI/R/2014/010
Synergy project Nr.
Homepage
Partner
University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

Because of a continuous increasing consumption of pharmaceutical products, their presence in the environment represents a serious environmental threat issue in industrialized countries. Pharmaceutical residues are introduced into the aquatic environment from numerous sources such as insufficiently treated sewage effluents, production residues, improper disposal of expired medications and unused drugs, accidental spillage during manufacturing and distribution. The continuous presence of pharmaceuticals in water bodies even at very low concentrations can lead to unwanted biological effects on aquatic species with the following impact on human health. Despite the high importance of this research area, there is still no sufficient scientific capacity and knowledge available in Norway and Latvia addressed to fully professional management of the issues of pharmaceutical residues. Therefore, the overall objective of the Project is to enhance the growth of research-based knowledge through the scientific cooperation between Norway and Latvia, developing a scientific capacity for the administration of pharmaceutical residues in the Latvian and Norwegian environment. As a result, the advanced high resolution mass spectrometric method will be introduced, diverse information about the contamination status will be obtained and the relevant training programs will be launched in the leading Universities of both countries. These activities will facilitate the execution of the general purpose to reduce risks related to the presence of pharmaceutical products in the environment.

Synergy project
The project is being implemented in synergy with the EEA/Norway Grants' scholarship project No. EEZ/NFI/S/2015/003. The scholarship project includes a direct synergy between the knowledge-transfer and research project with the participation of academic staff members of University of Latvia and Oslo University, through the theoretical and practical training in development and application of advanced mass spectrometric methods of analysis dedicated for assessment and control of pharmaceutical hazard distribution in food, and in the environment.

FINAL SUMMARY OF PROJECT ACTIVITIES: 

Project final report: ?d=Final_Report_010_VBartkevics_06_Jul_2017.docx (EN)
Reflection about the project most important data to the society: ?d=Sabiedri_bai_svari_ga_ko_projekta_iegu_to_datu_atspogul_ojuma_NFIR2014010_LV.docx (LV)

1) An UPLC-TOF-HRMS method for the assessment of 24 multi-class PPs in surface and tap water has been elaborated (WP2);
2) A bio-degradation model method of microorganisms adapted to specific pharmaceutical compounds (21 pharmaceutical compounds) based on activated sludge and biostimulation has been developed (WP3).
3) A data set (n = 103) of more than 25pharmaceutical products determined in wastewaters, surface water and tap water based on the elaborated analytical methods covering the concentration levels in Latvia and Norway aquifers has been developed (WP2).
4) Three internationally refereed scientific publications indexed by SCOPUS and two conference full page papers have been published (WP2, WP3)
5) Two internationally refereed joint scientific publications co-authored by project participants from both UL and UiO have been published in two peer reviewed scientific journals (Int. J. Environ. Sci. Technol. – impact factor: 2.5; Sci. Tot. Environ. – impact factor: 4.9 ) and four publications have been accepted for publication in scientific journals (WP2, WP3).
6) Seminary dedicated to research of PPs biodegradation in the environment to stakeholders has been held.
7) A projects final meeting on the 23th month of the project has been held to stakeholders of pharmacy industry, which included reports of the project results and discussion of management tasks of pharmaceutical residues and the efficiency of wastewater treatment plants.
8) The results of the method development and application studies were presented in three conferences held in Latvia, Riga (the 57th International conference of the Riga Technical University “Material Science &Applied Chemistry”); in a young scientist section in EcoBalt 2016, Tartu, Estonia, as well as in the third international conference Chemical Technology: Science and Production (the proceeding material) in Shostka, Ukraine, 2016.
9) A special section of EcoBalt 2016 conference included reports of 4 members, thus ensuring knowledge transfer to wide auditorium, including scientists and stakeholders.
10) The synergy between the research and scholarship activities was maintained and strengthened within a visit Prof. Elsa Lundanes (UiO, Norway) to Latvia – a guest lecture was held in the UL, Faculty of Chemistry in October 2016.
11) New researchers are involved in the research activities including two Dr.Chem. (Assoc. Prof. V. Bartkevics, Dr. S. Abele, Dr. G. Kizane, Dr. I. Nakurte, Dr. I. Pugajeva, Dr. Dz. Zacs), two PhD students ( Dr. I. Reinholds, PhD I. Perkons) and two M.sc.students.1).

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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Educational collaboration between Norway and Latvia for establishment of an effective risk assessment and control of pharmaceutical residues
Project funds
5971.00 EUR
Project term
01.08.2015 - 31.12.2015
Project Nr.
EEZ/NFI/S/2015/003
Synergy project Nr.
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv

Vadims Bartkevičs
Phone: +37126444153
E-mail: vadims.bartkevics@lu.lv

Partner
University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

E-mail: postmottak@admin.uio.no;
www.uio.no

Elsa Lundanes
Phone +4722855553
E-mail: elsa.lundanes@kjemi.uio.no

The overall mobility's objective is to enhance the transfer of knowledge and experience among UL and UiO academic staff working on environmental impact management of pollutant threats in Latvia and Norway, establishing the ecological monitoring and food safety systems, e.g. methods for assessment of impact factors, recommendations for control and prevention of threat to human health, economical benefit and the environment. Considering the actuality of chemical compound, especially the pharmaceutical residue, distribution in the environment and the possible hazard to human health, the assignment of new advanced researchers working is an essential priority regarding the environmental considerations of the EEA area. The activity of knowledge transfer into the UL educational programmes by staff will enhance the development of relevant educational and training programs launched in both countries (UL, UiO). Only the academic staff mobility is foreseen within the project.

Synergy project
The project is being implemented in synergy with the Norway Grants' research project No. NFI/R/2014/010. The scholarship project includes a direct synergy between the knowledge-transfer and research project with the participation of academic staff members of University of Latvia and Oslo University, through the theoretical and practical training in development and application of advanced mass spectrometric methods of analysis dedicated for assessment and control of pharmaceutical hazard distribution in food, and in the environment.

Total approved Project costs – 5 756.60 EUR. Altogether there are three academic staff mobilities implemented within the Project:

  1.        Three academic staff mobilities from Latvia to Norway.

Summary of Project results

The overall mobility’s objective was to enhance the transfer of knowledge and experience among UL and UiO academic staff working on environmental impact management of pollutant threats in Latvia and Norway, establishing the ecological monitoring and food safety systems (e.g. methods for assessment of impact factors), recommendations for control and prevention of threat to human health, economical benefit and the environment.

Over the course of the projects, three UL employees (Dr. Arturs Vīksna, Dr. Silvija Ābele and Dr. Vadims Bartkevics) undertook study visits to Norway. During the mobility there were undertaken lecture on occurrence of pharmaceutical compounds in the environment (drinking and surface water, sludge, sediments, biota etc), toxicity and methods of analysis of these substances was prepared and presented to students and teaching staff of the University of Oslo, discussions on research perspectives in area of control of pharmaceutical compounds in environmental samples were performed, information on occurrence data of pharmaceutical compounds in the environment of Latvia and Norway has been exchanged between the academic staff of University of Latvia and Oslo University and discussions on application of several instrumental methods (ultra high performance liquid chromatography coupled to tandem quadrupole mass spectrometry, hybrid quadrupole – Orbitrap or time-of-flight mass spectrometry) were done.

In addition the strategy for development of the laboratory capacity of the University of Latvia and Oslo University was discussed with a possible positive implication on implementation of common research projects.

Summary of Bilateral results

The mobility actions between the University of Oslo and University of Latvia have directly contributed to the establishment of contacts, experience and the long-term cooperation in research activities. Sharing the scientific experience in long term collaboration with the support form University of Oslo partners, the collaboration will be sustained between the competent leading experts to ensure the long-term cooperation in high quality research and knowledge transfer.

It is planned to ensure further sustainability of this project by both allocating the Erasmus+ funding or the funds available for bilateral cooperation activities, when necessary. In addition, the possibility to prepare the application proposal for additional scientific projects will be discussed upon announced future projects. An important factor ensuring the sustainability of mobility results is the synergy with the research component of the project No.NFI/R/2014/010 "Establishing of the scientific capacity for the management of pharmaceutical products residues in the environment of Latvia and Norway".

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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Project funds
41302.00 EUR
Project term
01.10.2015 - 30.09.2016
Project Nr.
EEZ/NFI/S/2015/031
Synergy project Nr.
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv

Nils Rostoks
Phone: +37167034862
E-mail: nils.rostoks@lu.lv

Partner
University of Oslo, Institute of Clinical Medicine
P.O. Box 1072, Oslo, 0316, Norvēģija

E-mail: postmottak@uio.no
http://www.uio.no/english

Alexandre Corthay
Phone: +4723074109
E-mail: alexandre.corthay@ibv.uio.no

University of Oslo, Institute of Basic Medical Sciences
P.O. Box 1072, Oslo, 0316, Norvēģija

E-mail: sekretariatet@basalmed.uio.no
http://www.med.uio.no/imb/english/

Gareth Sullivan
Phone: +4722851415
E-mail: gareth.sullivan@medisin.uio.no

Latvian Biomedical Research and Study Centre
Rātsupītes iela 1, Rīga, LV-1067, Latvija

E-mail: bmc@biomed.lu.lv
http://bmc.biomed.lu.lv/en/

Anna Zajakina
Phone: +37129150597
E-mail: anna@biomed.lu.lv

The Strategic Plan of the University of Latvia (UL) 2010-2020 appreciates an active involvement of students in mobility schemes, as this contributes to the excellence of student training and improves subsequently their employability. Mobility is also regarded as an utmost important tool for raising staff Academic qualification in the strategic policy documents of the University. According to the Development Strategy of UL the research is focused on multidisciplinarity and creation of synergy between both Latvian and foreign research institutions. Multilateral collaboration between UL, LBMC and UO will ensure knowledge transfer through a cooperation of groups with complementary expertise and implementation of internationally competitive research resulting in high-quality publications. Therefore this cooperation has a clear potential to provide new carrier opportunities for the involved young scientists. Both, the student and the academic staff mobility are foreseen within the project.

Synergy project
The project is being implemented in synergy with the Norway Grants' research project No. NFI/R/2014/051. The research project involves activities related to training of young researchers. The most talented and motivated students will develop their theses within the frame of high quality research project "Image-guided cancer gene therapy in combination with advanced chemotherapeutics". Students will visit laboratories of Norwegian partner to acquire methods and techniques not established in Latvia and to fulfil specific tasks within the frames of the project (WP4, WP7, WP8). It is planned that Master's students will participate in WP activities, including the investigation of therapeutic potential of alphaviral vectors, application of xenograft model for gene delivery studies and will visit the laboratory of Dr. A. Corthay in OUH to learn macrophage isolation and stimulation techniques (2-3 weeks). Students will transfer the knowledge to establish new techniques in LBMC.

Total approved Project costs – 30 707.13 EUR. Altogether there are two student and 11 academic staff mobilities implemented within the Project:

  1.        Two student mobilities from Latvia to Norway;
  2.        25 ECTS received;
  3.        Three academic staff mobilities from Latvia to Norway;
  4.        Eight academic staff mobilities from Norway to Latvia.
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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Strengthening and transferring the intellectual capital among geographers in Latvia and Norway
Project funds
72974.00 EUR
Project term
30.06.2015 - 30.09.2016
Project Nr.
EEZ/NFI/S/2015/009
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv
Zaiga Krišjāne
Phone: +37129153746
E-mail: zaiga.krisjane@lu.lv

Partner
Arctic University of Norway
Bok 5060 Langnes, Tromso, N-9037, Norvēģija

E-mail: postmottak@uit.no
www.en.uit.no
Marit Aure
Phone: +4741240034
E-mail: marit.aure@uit.no

University of Bergen
Muséplass 1, Postboks 7800, Bergen, N-5020, Norvēģija

E-pasts: postmottak@uit.no
www.uit.no 
Kerstin Potthoff
Tālrunis: +4755583093
E-pasts: kerstin.potthoff@geog.uib.no

The Strategic Plan of the UL 2010-2020 appreciates tight involvement of students in mobility schemes, as this contributes to the students' cross-border study experience, personal growth and prospective involvement in research activities. Staff mobility is considered beneficial for raising academic personal excellence in terms of life-long learning and exchange of experience. The UL Vision and international cooperation strategy emphasize the significance of regional and cross-border cooperation between the UL and other academic institutions of the Baltic Sea Region and EU countries working towards common goals for social and economic development. The study programs in geography at the UL offer courses on planning yet the aspects of local development and landscape potentialities are only partially presented there. The Department of Geography is interested in advancing these topics through a knowledge transfer process by staff and students' involvement in international collaboration. 2 staff members, 3 PhD and some master students currently are developing themes on social and landscape planning, and democracy in practice through public participation. The experts from Regional Development and Landscape Geography at the Department of Geography (UiB) have a strong track-record in research addressing rural landscapes and development. The Department of Geography at UL is the most experienced institution in Latvia regarding large-scale migration research. Currently, 4 PhD and several master students are developing their thesis on migration. Centre for women's and gender research KVINNFORSK at UiT have experience in research of geographical mobilities in the High North. Mobility will engage students creating long-term contribution to the development of research competence within the field of migration. The exchange visits of personnel will contribute to come up with advanced theoretical and methodological interdisciplinary solutions to study youth mobility in Europe. Both, the student and the academic staff mobility are foreseen within the project.

Altogether there are 6 student and 9 academic staff mobilities implemented within the Project:

  1.        Six student mobilities from Latvia to Norway;
  2.        160 ECTS received;
  3.        Six academic staff mobilities from Latvia to Norway;
  4.        Three academic staff mobilities from Norway to Latvia.
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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Mobility in political science and sociology
Project funds
109568.00 EUR
Project term
01.09.2015 - 31.08.2016
Project Nr.
EEZ/NFI/S/2015/024
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv
Iveta Reinholde
Phone: +37129127742
E-mail: iveta.reinholde@lu.lv

Partner
Oslo and Akershus University College of Applied Sciences
P.O. Box 4 St. Olavs plass, Oslo, N-0130, Norvēģija

E-mail: postmottak@hioa.no
www.hioa.no
Kristel Mari Skorge
Phone: +4722453510
E-mail: kristel-mari.skorge@hioa.no

Ostfold University College
Bra veien 4, Halden, 1757, Norvēģija

E-mail: postmottak@hiof.no
www.hiof.no
Henrik Sætra
Phone: +4769215275
E-mail: henrik.satra@hiof.no

The overall goal of the Project is to increase the teaching and research capacity in institutions of higher education in Latvia and Norway. This project seeks to increase the quality and the volume of student and teaching staff mobility between the partner institutions in the thematic area of political science, public administration and sociology. Staff and student mobility will result in long term impact on both sides via: - Development of joint study courses; - Curriculum development for joint study programme and life-long learning modules; - Joint research activities. These results will achieved based on joint interests of partners, their cooperation experience and will to deepen cooperation with future sustainable effects for all partners. The main sustainable benefits will deal with internationalization of studies, capacity building and development of joint Baltic Sea research area. Partners - Oslo and Akershus University College of Applied Sciences and Østfold University College were selected based on previous cooperation experience in teaching and joint research activities having resulted in more than 20 scientific publications. This project is intended to deepen cooperation in more structured way. Both, the student and the academic staff mobility are foreseen within the project.

Altogether there are eight student and 32 academic staff mobilities implemented within the Project:

  1.        Seven student mobilities from Latvia to Norway;
  2.        One student mobilities from Norway to Latvia;
  3.        77 ECTS received;
  4.        26 academic staff mobilities from Latvia to Norway;
  5.        Six academic staff mobilities from Norway to Latvia.
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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Mobility in Language, Culture and Gender Studies
Project funds
89451.00 EUR
Project term
01.08.2015 - 30.09.2016
Project Nr.
EEZ/NFI/S/2015/022
Synergy project Nr.
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv

Ausma Cimdiņa
Phone: +3717034859
E-mail: ausma.cimdina@lu.lv

Partner
University of Iceland, School of Humanities
Aðalbygging Háskóla Íslands Sæmundargata 2, Reykjavík, 101, Islande

E-mail: hug@hi.is
www.hi.is

Gunnella Thorgeirsdóttir
Phone: +3545254406
E-mail: gunnella@hi.is

Institute of Health and Society, University of Oslo
Box 1072, Blindern, Oslo, NO-0316, Norvēģija

E-mail: fa-admin@admin.uio.no
www.uio.no
Anne, Kveim Lie
Phone: +4722850607
E-mail: a.h.k.lie@medisin.uio.no

Centre for Gender Research at the University of Oslo
P.O. Box 1040 Blindern, Oslo, N-0315, Norvēģija

E-mail: postmottak@stk.uio.no
http://www.stk.uio.no/english/
Hoffart, Amund Rake
Phone: +4722858973
E-mail: a.r.hoffart@stk.uio.no

University of Tromso
Hansine Hansens veg 18, Tromsø, 9019, Norvēģija

E-mail: postmottak@uit.no
www.uit.no
Jørgen Fossland
Phone: +4747702271
E-mail: jorgen.fossland@uit.no

University of Iceland
Sæmundargötu 2, Reykjavík, 101, Islande

E-mail: aripk@hi.is
http://www.hi.is
http://www.arnastofnun.is
Ari Pall Kristinsson
Phone: +3545254442
E-mail: aripk@hi.is

The Centre for Gender Research at the University of Oslo (UiO) is the largest gender research centre in Norway, so collaboration will contribute to the improvement of the quality of education, achieved by the inclusion of the Norwegian experience on gender issues into the contents of the University of Latvia study courses. Collaboration with the Institute of Health and Society from the UiO allows to exchange the research experience and contributes to creation of the Erasmus+ exchange agreement and plan, as well as to discussion of a possibility to work out a project in the frames of the programme Horizon 2020, Health for Growth. The Icelandic experience in a wider Baltic-Nordic context is significant, since there are common features in language standardization and language education policies in both countries. Collaboration between the UL and Tromsø will promote exchange of Northern and Baltic experience and improvement of both theoretical linguistics and Latvian Studies. Both, the student and the academic staff mobility are foreseen within the project.

Synergy project
The project is being implemented in synergy with the Norway Grants' research project No. NFI/R/2014/061. Master and PhD students' involvement in research project through data collection, assisting in drafting and co-authoring publications on research results, development of research project-based doctoral thesis; involvement of academic staff in research project to design the lecturing course for the PhD school and develop new study courses involving Norwegian experience on gender sociality and female studies issues.

Total approved Project costs – 46 181.20 EUR. Altogether there are six student and 12 academic staff mobilities implemented within the Project:

  1.        Six student mobilities from Latvia to Norway;
  2.        90 ECTS received;
  3.        Six academic staff mobilities from Latvia to Norway and three to  Iceland;
  4.        One academic staff mobilities from Norway and two from Iceland to Latvia.
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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Economics and Management Student and Teacher Mobility between University of Latvia and University of Agder
Project funds
19260.00 EUR
Project term
01.08.2015 - 30.09.2016
Project Nr.
EEZ/NFI/S/2015/002
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv
Ramona Rupeika-Apoga
Phone: +37129331977
E-mail: rr@lu.lv

Partner
University of Agder, School of Business and Law
Servicebox 422, Kristiansand, N-4604, Norvēģija

E-mail: post@uia.no
www.uia.no
Ingunn Galteland
Phone: +4738141171
E-mail: Ingunn.galteland@uia.no

The overall purpose of the project is to establish, develop and strengthen educational co-operation in the economics and management area between UL and AiU. The project will provide an opportunity for both partners to share experience and best practice, promote collegial interaction, collaborate on student mobility projects, provide the basis for further academic staff co-operation between both partner universities and expand joint study possibilities. Both, the student and the academic staff mobility are foreseen within the project.

Total approved Project costs – 17 698.67 EUR. Altogether there are one student and seven academic staff mobilities implemented within the Project:

  1.        One student mobility from Latvia to Norway;
  2.        30 ECTS received;
  3.        Three academic staff mobilities from Latvia to Norway;
  4.        Four academic staff mobilities from Norway to Latvia.
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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities
Project funds
85514.00 EUR
Project term
01.08.2015 - 30.09.2016
Project Nr.
EEZ/NFI/S/2015/019
Synergy project Nr.
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv

Juris Barzdins
Phone: +37129267827
E-mail: juris.barzdins@lu.lv

Partner
University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

E-mail: jens.bollerslev@medisin.uio.no
www.uio.no

Jens Bollerslev
Phone: +4723071923
E-mail: jens.bollerslev@medisin.uio.no

University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

E-mail: k.i.birkeland@medisin.uio.no
www.uio.no
Kåre I. Birkeland
Phone: +4723034587
E-mail: k.i.birkeland@medisin.uio.no

University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

E-mail: ivar.gladhaug@rikshospitalet.no
www.uio.no
Jens Pahnke
Phone: +4723071466
E-mail: jens.pahnke@medisin.uio.no

University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

http://www.ous-research.no/biochemistry/
Alicia Llorente
Phone: +4722781825
E-mail: alillo@rr-research.no

University of Oslo
Boks 1072 Blindern, Oslo, 0316, Norvēģija

E-mail: postmottak@admin.uio.no;
www.uio.no
Elsa Lundanes
Phone +4722855553
E-mail: elsa.lundanes@kjemi.uio.no

Norwegian University of Science and Technology (NTNU), Department of Public Health and General Practice
Post box 8905 MTFS, Trondheima, 7491, Norvēģija

E-mail: Ism-post@medsin.ntnu.no
www.ntnu.no / www.ntnu.edu
Aslak Steinsbekk
Phone: +4773597574
E-mail: aslak.steinsbekk@ntnu.nu

The Project is aimed to enhancing human capital and knowledge base at the Faculty of Medicine, University of Latvia (LU) and increasing the institutional cooperation in research and development with the Norwegian University of science and technology (NTNU), the University of Oslo (UiO) and the University of Bergen (UiB) by promoting partnerships and mobility between universities of both countries, and increasing the capacity and competence-building in the LU. Taking into account the multidisciplinary research activities carried out in LU, it is necessary to improve the competence in the diverse fields through the sharing knowledge among partner universities to increase the scientific and teaching productivity of the LU. Both, the student and the academic staff mobility are foreseen within the project.

Synergy project
The project is being implemented in synergy with the Norway Grants' research project No. NFI/R/2014/023 and NFI/R/2014/0451. Related to NFI/R/2014/023, Latvian PhD students will be trained for stereotactic mouse surgery and infusion techniques in Norway. They will achieve further knowlege through seminars held within consortium. Treatment approaches of amyloid extrusion over the barriers of the brain, antibody based or ABC transporter based , will significantly improve when combined with the approaches generated thoughout the project. Related to NFI/R/2014/045, the project team includes PhD and MSc degree students affiliated to LU whose individual study plan will be tailored to include visits to the Oslo University Hospital (OUS) in conjunction with the Scholarship activity. Consortium activities will be planned in synergy to allow research team mobility and knowledge exchange between OUS and LU. The main tasks of the visits will be to develop standard procedures for the isolation of EVs from biofluids and to gain experience in studying the mechanisms of EV release and uptake.

Total approved Project costs – 77 168.40 EUR. Altogether there are nine student and 15 academic staff mobilities implemented within the Project:

  1.        Nine student mobilities from Latvia to Norway;
  2.        134 ECTS received;
  3.        11 academic staff mobilities from Latvia to Norway;
  4.        Four academic staff mobilities from Norway to Latvia.
Image-guided cancer gene therapy in combination with advanced chemotherapeutics (PROJECT COMPLETED)
Cancer derived extracellular vesicles: function and clinical applications in prostate cancer (PROJECT COMPLETED)
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
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Promoter
Latvian Biomedical Research and Study Centre
Address
Rātsupītes iela 1, Rīga, LV-1067, Latvija
Project name
Image-guided cancer gene therapy in combination with advanced chemotherapeutics (PROJECT COMPLETED)
Project funds
478440.00 EUR
Project term
01.05.2015 - 30.04.2017
Project Nr.
NFI/R/2014/051
Synergy project Nr.
Homepage
Partner
Oslo University Hospital
Postboks 4950 Nydalen, OSLO, 0424
Organic Synthesis Institute of Latvia
Aizkraukles 1, LV-1006, Rīga

The proposed project presents a new collaborative research initiative within the field of cancer therapy. Our main objective is to perform preclinical evaluation of a novel therapeutic strategy against cancer cells based on a combination of chemotherapeutic drugs with viral gene therapy vectors. We propose to apply novel alphaviral vectors encoding cytokines, which able to stimulate tumor-associated macrophage (TAM) infiltration into the tumor and induction of pro-inflammatory microenvironment to block tumor recovery after chemotherapy. Several mouse models of breast cancer, melanoma and xenograft model of human lung carcinoma will be treated with chemical compounds with significant anti-proliferative properties followed by the application of alphaviral vectors. The outcomes of treatment will be monitored using advanced imaging technologies including bioluminescent and fluorescent imaging. The molecular mechanism underlying the alphaviral tumor tropism will be investigated in details using a comparative proteome analysis of cancer cells susceptible and unsuceptible to alphaviral invection. Therefore, the aim of this study is to develop an efficient strategy for cancer treatment based on an application of image-guided targeted chemotherapeutics in combination with gene therapy vectors. Special attention will be paid to training of young researchers in cutting-edge imaging techniques, advanced immunological methods and mass spectrometry approaches. The research credibility is justified by the broad and complementary expertise of participating groups from three institutions: Latvian Institute of Organic Synthesis (LIOS); Latvian Biomedical Research and Study Centre (LBMC); Oslo University Hospital (OUH).

Synergy project
The project is being implemented in synergy with the EEA/Norway Grants' scholarship project No. EEZ/NFI/S/2015/031. The research project involves activities related to training of young researchers. The most talented and motivated students will develop their theses within the frame of high quality research project "Image-guided cancer gene therapy in combination with advanced chemotherapeutics". Students will visit laboratories of Norwegian partner to acquire methods and techniques not established in Latvia and to fulfil specific tasks within the frames of the project (WP4, WP7, WP8). It is planned that Master's students will participate in WP activities, including the investigation of therapeutic potential of alphaviral vectors, application of xenograft model for gene delivery studies and will visit the laboratory of Dr. A. Corthay in OUH to learn macrophage isolation and stimulation techniques (2-3 weeks). Students will transfer the knowledge to establish new techniques in LBMC.

Project final report: ?d=LV_final_report_form_Research051_2017_FINAL.doc (LV)
Publication: ?d=Publikacija_publication.zip (RU)

The project contributes to development of new anti-cancer therapies based on alphaviral vectors expressing immunomodulating cytokines and 1,4-dihydropiridine-based chemotherapeutics with fluorescent properties. The main idea of the project was to design viral vectors for activation of tumorocidal functions of tumor assotiated macrophages, which will be applied in combination with chemical drugs possessing antiproliferative as well as infrared-spectrum emission characteristics.

Several recombinant Semliki Forest (SFV) and Sindbis (SIN) virus  vectors encoding either tumor necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) were developed. The vectors showed high infection rate and cytotoxicity in mouse and human cancer cells in vitro (lung and breast cancer models). By contrast, mouse and human macrophages were resistant to infection with SFV. The recombinant SFV vectors directly inhibited mouse lung carcinoma cell growth in vitro, while exploiting the cancer cells for production of SFV vector-encoded cytokines. The functionality of SFV vector-derived TNF-alpha was confirmed through successful induction of cell death in TNF-alpha-sensitive fibroblasts in a concentration-dependent manner. The SFV vector-derived IFN-gamma activated macrophages toward a tumoricidal M1 phenotype leading to suppressed lung carcinoma cell growth in vitro. The ability of SFV to provide functional cytokines and to infect tumor cells but not macrophages suggests that SFV may be very useful for cancer immunotherapy employing tumor-infiltrating macrophages.

In a frame of development of novel chemotherapeutics, three potential anti-cancer drugs were selected for combined treatment with alphaviral vectors. The compounds demonstrated inhibition of Lewis lung carcinoma growth through induction of necrosis of tumor nodules, as was confirmed by histochemical analysis of tumors. Fluorescent properties of the compounds were evaluated using microscopy and in vivo imaging system. More than ten compounds and linkers were designed and synthesized in order to improve their tumor targeting properties and fluorescence characteristics. The next step will include the attachment of tumor homing ligands to the most promising compounds.

Furthermore, a mouse model based on patient derived tumor xenografts was developed and comprehensively characterised in terms of immune cell composition and growth dynamics. The model allows evaluation of therapeutic effects in presence of human immune cells, which are transplanted within the xenograft pieces.

In summary, although the obtained results were fruitful, the implemented project represents a beginning of collaborative research initiative between Latvia and Norway in the field of cancer therapy. The involved groups with complementary expertize have a clear vision of sustainable collaboration. Practically, next steps will include further development of anti-cancer drugs, evaluation of 1,4-dihydropiridine-based drugs in PDX models, activation of human macrophages with alphaviral vectors and optimization of vector delivery mode in mouse allograft and human xenograft models.

The project resulted in six articles in international peer-reviewed journals (four published, one accepted and one submitted for publication), two of them are joint publication. 

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Promoter
Latvian Biomedical Research and Study Centre
Address
Rātsupītes iela 1, Rīga, LV-1067, Latvija
Project name
Cancer derived extracellular vesicles: function and clinical applications in prostate cancer (PROJECT COMPLETED)
Project funds
486485.00 EUR
Project term
01.05.2015 - 30.04.2017
Project Nr.
NFI/R/2014/045
Synergy project Nr.
Partner
Oslo University Hospital
Postboks 4950 Nydalen, OSLO, 0424
University of Latvia, Faculty of Medicine
Raiņa bulvāris 19, Rīga, LV-1586

Extracellular vesicles (EVs) have recently emerged as important mediators of intercellular communication and been implicated in the regulation of physiological and pathological processes, including cancer. Cancer-derived EVs contain disease-related molecules, and therefore EVs in biological fluids may serve as a "liquid biopsy" enabling patient stratification and monitoring of treatment response. In addition, molecular analysis of cancer-derived EVs may provide novel insights into how cancer cells and tumour-host communicate and drive cancer progression. Importantly, this may lead to the discovery of novel targets for therapeutic intervention, The overall objective of this project is to delineate the role of cancer-derived EVs in the progression of prostate cancer (PC) and to identify EV-enclosed small RNAs associated with cancer aggressiveness that can serve as potential therapeutic targets and/or prognostic biomarkers of prostate cancer. The specific aims are: (1) To characterize (size, marker profile, RNA content) and compare EV subpopulations released by highly aggressive and indolent PC cells, using various PC cell models; (2) To gain insight into EV tropism and functional effects in the tumour microenvironment and metastatic niche; (3) To explore EV biodistribution and impact on survival and anti-tumour immune response in a mouse model of PC; (4) To establish a repository of standardised and well-documented clinical material collected from PC and benign prostatic hyperplasia (BPH) patients that will serve as a resource for testing and validating RNA biomarker candidates and for studying the uptake of EVs by recipient cells; (5) To establish methods for testing RNA biomarker candidates in EVs isolated from biofuids of PC and BPH patients and to evaluate their prognostic relevance.

Synergy project
The project is being implemented in synergy with the EEA/Norway Grants' scholarship project No. EEZ/NFI/S/2015/019 and research project No. NFI/R/2014/023. Related to NFI/R/2014/023, Latvian PhD students will be trained for stereotactic mouse surgery and infusion techniques in Norway. They will achieve further knowlege through seminars held within consortium. Treatment approaches of amyloid extrusion over the barriers of the brain, antibody based or ABC transporter based , will significantly improve when combined with the approaches generated thoughout the project. Related to NFI/R/2014/045, the project team includes PhD and MSc degree students affiliated to LU whose individual study plan will be tailored to include visits to the Oslo University Hospital (OUS) in conjunction with the Scholarship activity. Consortium activities will be planned in synergy to allow research team mobility and knowledge exchange between OUS and LU. The main tasks of the visits will be to develop standard procedures for the isolation of EVs from biofluids and to gain experience in studying the mechanisms of EV release and uptake.

Project final report: ?d=045_Final_Report_27.06.2017.docx (EN)
Publications: ?d=Publikacijas_publications.zip

The main scientific objective of the project was to delineate the role of cancer-derived extracellular vesicles (EVs) in the progression of prostate cancer (PC) and to identify EV-enclosed RNA biomarkers associated with cancer aggressiveness that can serve as potential therapeutic targets and/or prognostic biomarkers of prostate cancer.

Within this project, we carried out several studies focused on the characterisation of RNA, protein and lipid content of EVs released by PC cell lines or found in the blood and urine of PC patients. These studies resulted in the identification of EV-incorporated miRNAs and proteins that potentially can serve as biomarkers for the diagnosis and monitoring of PC. Furthermore, we performed a systematic comparison of PC-associated miRNA levels in whole plasma and EVs isolated from the same plasma samples. This showed that EVs provide a more consistent source of RNA than whole plasma for the analysis of some miRNA biomarkers, while, possibly due to specific sorting mechanisms, the abundance of other miRNAs in EVs is very low and they show better diagnostic performance in whole plasma. A novel model for quantifying the uptake of EVs in human immune cells using continuous and nearly physiologically relevant amounts of cancer-derived EVs was developed. Functional studies demonstrated that cancer-derived EVs are taken up by a variety of immune cells, including macrophages, T and B cells, which are found in the tumour microenvironment. In macrophages, cancer-derived EVs stimulated secretion of pro-inflammatory chemokines and cytokines, however the effect was dependent on the polarisation state of macrophages before exposure to the EVs.

Results of this project are included in 10 international publications (4 published, 6 submitted) and two local scientific publications (1 published, 1 submitted) and presented at 5 international scientific conferences, meetings of the EU COST action Me-HAD and other workshops. The public outreach activities included participation in the European Researcher’s Night, open seminars, presentations at the annual LU scientific conference, publications on the institutional webpages and in popular science journal.

This project formed synergy with the project „Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities” that allowed 5 PhD students to visit Oslo University and Oslo University Hospital. During the visits the students undertook various courses at University of Oslo and underwent hands-on training at the OUH laboratories thus gaining new knowledge and experience that was highly relevant for the research project and their PhD studies.

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Promoter
University of Latvia
Address
Raiņa Bulvāris 19, Rīga, LV-1586
Project name
Mobility of students and academic personnel of Life Sciences between Latvia and Norway
Project funds
41302.00 EUR
Project term
01.10.2015 - 30.09.2016
Project Nr.
EEZ/NFI/S/2015/031
Synergy project Nr.
Homepage
Project promoter contact info

E-mail: lu@lu.lv;
www.lu.lv

Nils Rostoks
Phone: +37167034862
E-mail: nils.rostoks@lu.lv

Partner
University of Oslo, Institute of Clinical Medicine
P.O. Box 1072, Oslo, 0316, Norvēģija

E-mail: postmottak@uio.no
http://www.uio.no/english

Alexandre Corthay
Phone: +4723074109
E-mail: alexandre.corthay@ibv.uio.no

University of Oslo, Institute of Basic Medical Sciences
P.O. Box 1072, Oslo, 0316, Norvēģija

E-mail: sekretariatet@basalmed.uio.no
http://www.med.uio.no/imb/english/

Gareth Sullivan
Phone: +4722851415
E-mail: gareth.sullivan@medisin.uio.no

Latvian Biomedical Research and Study Centre
Rātsupītes iela 1, Rīga, LV-1067, Latvija

E-mail: bmc@biomed.lu.lv
http://bmc.biomed.lu.lv/en/

Anna Zajakina
Phone: +37129150597
E-mail: anna@biomed.lu.lv

The Strategic Plan of the University of Latvia (UL) 2010-2020 appreciates an active involvement of students in mobility schemes, as this contributes to the excellence of student training and improves subsequently their employability. Mobility is also regarded as an utmost important tool for raising staff Academic qualification in the strategic policy documents of the University. According to the Development Strategy of UL the research is focused on multidisciplinarity and creation of synergy between both Latvian and foreign research institutions. Multilateral collaboration between UL, LBMC and UO will ensure knowledge transfer through a cooperation of groups with complementary expertise and implementation of internationally competitive research resulting in high-quality publications. Therefore this cooperation has a clear potential to provide new carrier opportunities for the involved young scientists. Both, the student and the academic staff mobility are foreseen within the project.

Synergy project
The project is being implemented in synergy with the Norway Grants' research project No. NFI/R/2014/051. The research project involves activities related to training of young researchers. The most talented and motivated students will develop their theses within the frame of high quality research project "Image-guided cancer gene therapy in combination with advanced chemotherapeutics". Students will visit laboratories of Norwegian partner to acquire methods and techniques not established in Latvia and to fulfil specific tasks within the frames of the project (WP4, WP7, WP8). It is planned that Master's students will participate in WP activities, including the investigation of therapeutic potential of alphaviral vectors, application of xenograft model for gene delivery studies and will visit the laboratory of Dr. A. Corthay in OUH to learn macrophage isolation and stimulation techniques (2-3 weeks). Students will transfer the knowledge to establish new techniques in LBMC.

Total approved Project costs – 30 707.13 EUR. Altogether there are two student and 11 academic staff mobilities implemented within the Project:

  1.        Two student mobilities from Latvia to Norway;
  2.        25 ECTS received;
  3.        Three academic staff mobilities from Latvia to Norway;
  4.        Eight academic staff mobilities from Norway to Latvia.
Latvian language in monolingual and bilingual aquisitions: tools, theories and applications (PROJECT COMPLETED)
Health ans Social Indicators of participation in Physical Activities for Children with Disabilities
Educational for Sustainable Development
Research-based Teaching of Language Acquisition (in synergy with Research activity project "Latvian language in Monolingual and Bilingual Acquisition: tools, theories and applications")
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